文章摘要
夏蔡虹,李 军**,盛国荣**.银连祛风汤治疗慢性荨麻疹的临床疗效及对辅助性 T细胞因子表达水平的调节作用*[J].药学与临床研究,2020,28(2):93~96
银连祛风汤治疗慢性荨麻疹的临床疗效及对辅助性 T细胞因子表达水平的调节作用*
Clinical Effect of Yinlianqufeng Decoctions on Chronic Urticaria and the Regulation Expressions of Cytokines of Helper T Cell*
投稿时间:2020-02-07  修订日期:2020-04-24
DOI:
中文关键词: 慢性荨麻疹  银连祛风汤  辅助性T细胞  临床疗效  IFN-γ  IL-2  IL-4
英文关键词: Chronic Urticaria  Yinlianqufeng Decoction  Clinical efficacy  IFN-γ  IL-2  IL-4
基金项目:江苏省药学会-奥赛康医院药学基金项目(A201952)
作者单位E-mail
夏蔡虹 南通汉药中医医院 ntsgr@126.com 
李 军** 南通汉药中医医院  
盛国荣** 南通市药学会 ntsgr@126.com 
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中文摘要:
      目的:探讨银连祛风汤治疗慢性荨麻疹的疗效及对外周血辅助性T细胞(Th1/Th2)相关细胞因子表达水平的影响。方法:将92例慢性荨麻疹患者随机分为银连祛风汤组和地氯雷他啶分散片组,各46例,分别用上述药物治疗,疗程均为8周,观察临床疗效和复发率。另选健康体检者30例作为正常对照组。采用ELISA法测定血清Thl、Th2细胞因子IFN-γ、IL-2、IL-4的表达水平。结果:银连祛风汤组有效率89.13%(41/46)与地氯雷他啶分散片组的有效率80.43%(37/46)比较差异无统计学意义(P>0.05);银连祛风汤组复发率14.63%(6/41),低于地氯雷他啶分散片组的35.14% Chronic Urticaria; Yinlianqufeng Decoction; Helper T Cell; Clinical efficacy; IFN-γ; IL-2; IL-4(13/37),差异有统计学意义(P<0.05)。治疗前,两组患者血清IFN-γ、IL-2、IL-4水平差异无统计学意义(P>0.05);治疗后,两组均明显升高IFN-γ、IL-2水平,降低IL-4水平,与治疗前比较,差异均有统计学意义(P<0.01),银连祛风汤组升高IFN-γ、IL-2水平、降低IL-4水平更明显,与地氯雷他啶分散片组比较,差异均有统计学意义(P<0.05 or P<0.01)。结论:银连祛风汤治疗慢性荨麻疹疗效显著,可能是通过纠正失衡的Th1/Th2相关细胞因子的表达水平发挥了作用。
英文摘要:
      Objective: To investigate the effect of Yinlianqufeng decoctions on chronic urticaria and its effect on the expression of Th1/Th2 cytokines in peripheral blood. Methods: Ninety-two patients with chronic urticaria were randomly divided into Yinlianqufeng decoctions group and desloratadine dispersive tablets group, with 46 patients in each group. After 8 weeks of treatment, the clinical efficacy and recurrence rates were observed. Thirty healthy subjects were selected as the control group. Serum levels of Thl/Th2 cytokines, IFN-gamma, IL-2 and IL-4 were determined by ELISA. Results: The difference of effective rates between the Yinlianqufeng decoctions group 89.13% (41/46) and the desloratadine dispersive tablets group 80.43%(37/46) was not statistically significant (P>0.05). The recurrence rate of the yinlianqufeng decoctions group was 14.63%(6/41), which was lower than that of the desloratadine dispersive tablets group 35.14%(13/37), and the difference was statistically significant (P<0.05). Before treatment, there was no significant difference in IFN-γ, IL-2 and IL-4 between the two groups (P>0.05) .After treatment, the levels of IFN-gamma and IL-2 were increased and the levels of IL-4 were decreased in both groups (P<0.01), and the changes were more significant in the Yinlianqufeng decoctions group than in the desloratazine dispersive tablets group (P<0.05 or P<0.01). Conclusion: Yinlianqufeng decoctions have significant therapeutic effects on chronic urticaria, probablely by correcting the imbalance of Th1/th2-related cytokines.
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