文章摘要
李祥,蓝晓红,许锐,吴冬妮,陈曙东,周永刚.以降钙素原水平指导慢阻肺急性加重患者抗感染治疗的研究[J].药学与临床研究,2020,28(5):341~344
以降钙素原水平指导慢阻肺急性加重患者抗感染治疗的研究
Anti-infection Treatment Guided by Procalcitonin in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease
投稿时间:2017-11-06  修订日期:2020-10-20
DOI:
中文关键词: 降钙素原  抗感染  慢性阻塞性  肺疾病
英文关键词: Procalcitonin  Anti-infection  Lung disease  Chronic obstructive
基金项目:江苏省药学会科研项目(201506)
作者单位E-mail
李祥 南京中医药大学附属八一医院药学科 210002 lixiang0921@126.com 
蓝晓红 南京中医药大学附属八一医院药学科 210002  
许锐 南京中医药大学附属八一医院药学科 210002  
吴冬妮 南京中医药大学附属八一医院药学科 210002  
陈曙东 南京中医药大学附属八一医院药学科 210002  
周永刚 南京中医药大学附属八一医院药学科 210002 zhouyang1300@126.com 
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中文摘要:
      目的:通过降钙素原(PCT)与慢性阻塞性肺病(慢阻肺)急性加重(AECOPD)诊治专家共识,推荐以症状评估方法为主导的抗感染治疗策略的比较,旨在为AECOPD患者抗菌药物临床合理使用提供依据。方法:选取2016年6月~2019年6月因AECOPD住院治疗,肺功能为中、重度损害的患者113例,按随机数字表法分为对照组(专家共识指导组)60例和治疗组(PCT指导组)53例。对照组根据“共识”作抗菌治疗,治疗组在PCT≥0.25 μg·L-1时作抗菌治疗。结果:治疗组与对照组比较,抗菌药物使用率无显著性差异(P>0.05),抗菌药物平均使用时间、平均住院时间显著降低(P<0.05)。结论:PCT可以有效指导肺功能为中、重度损害的AECOPD患者的抗感染治疗,特别是在疗程的把握上具有较强优势。
英文摘要:
      Objective: To compare the anti-infective treatment strategies, on acute exacerbation of chronic obstructive pulmonary disease (AECOPD), guided by procalcitonin (PCT) levels or recommended by expert consensus, in order to provide a basis for the rational clinical use of antimicrobials in patients with AECOPD. Methods: From June 2016 to June 2019, 113 patients with moderate or severe lung function impairment due to AECOPD were selected for hospitalization. According to the random number table, they were divided into control group (60 cases under consensus guidance) and treatment group (53 cases under PCT guidance). The patients in the control group started antibacterial treatment based on consensus recommendations, and those in the treatment group received anti-infective treatment when PCT≥0.25 μ·L-1. Results: There was no significant difference in the use rate of antibiotics between the treatment group and the control group (P>0.05). Compared with the control group, the average use time of antibiotics and the average length of stay for the treatment group were significantly reduced (P<0.05). Conclusion: PCT can effectively guide the anti-infective treatment of AECOPD patients with moderate to severe lung function impairment, especially in the control of treatment courses, which has a strong advantage.
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