文章摘要
许小英,周存敏,谭榜云,陈琳,朱海平.黄芪多糖纳米粒的构建及特征[J].药学与临床研究,2020,28(5):333~337
黄芪多糖纳米粒的构建及特征
Construction and Characteristics of Astragalus Polysaccharide Nanoparticles
投稿时间:2020-06-17  修订日期:2020-10-20
DOI:
中文关键词: 黄芪多糖  纳米粒  物理特征
英文关键词: Astragalus polysaccharide  Nanoparticles  Physical characteristic
基金项目:甘肃省中医药管理局科研课题(GZK-2016087);兰州大学第一医院院内基金资助项目(ldyyyn2017-05)
作者单位E-mail
许小英 兰州大学第一医院 xiaoying.1123@163.com 
周存敏 兰州大学第一医院  
谭榜云 兰州大学第一医院  
陈琳 兰州大学第一医院  
朱海平 兰州大学第一医院  
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中文摘要:
      目的:借助纳米技术制备成APS纳米粒。方法:根据离子交联原理制备APS纳米粒。通过红外吸收光谱分析、粒径、Zeta电位,表征其物理特性,并将该纳米粒与大鼠心肌细胞共培养,评价细胞相容性。结果:该药物的红外吸收光谱在618.3 cm-1处出现特征吸收峰,平均粒径为112.4 nm,Zeta电位为(41.0±0.21)mV,与H9c2细胞共培养后细胞活力无显著性变化(P=0.557)。结论:制成APS纳米粒,此纳米粒粒径分布均匀,性质稳定,具有良好的细胞相容性。
英文摘要:
      Objective: The astragalus polysaccharide nanoparticles (APS-CS NPs) were prepared by the nanotechnology for the application of traditional Chinese medicine. Methods: APS-CS NPs were prepared using the ionic gelation technique. Then fourier transform infrared (FTIR) spectra, sizes and zeta potentials were analyzed to evaluate their physical characteristics. Finally, they were co-cultured with cardiomyocytes, and their cell compatibility were evaluated. Results: FTIR spectra of the APS-CS NPs showed a characteristic absorption peak at the frequency of 618.3 cm-1. The average particle size was 112.4 nm and the zeta potential was 41.0±0.21. There was no significant change in cell viability after co-cultivation of the nanomedicine with H9c2 cells (P=0.557). Conclusion: APS-CS NPs with uniform particle size, regular morphology and good biocompatibility has been successfully prepared.
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