文章摘要
周谧,朱琳,傅兴圣.干蟾皮炮制前后两种毒性成分的含量比较[J].药学与临床研究,2021,29(4):256~258
干蟾皮炮制前后两种毒性成分的含量比较
Traditional Chinese medicine quality control; Bufo bufo gargarizans; Cinobufagin; Resibufogenin; HPLC
投稿时间:2020-11-05  修订日期:2021-08-17
DOI:
中文关键词: 干蟾皮  制干蟾皮  华蟾酥毒基  脂蟾毒配基  高效液相色谱法
英文关键词: traditional Chinese medicine quality control  Bufo bufo gargarizans  Cinobufagin  Resibufogenin  HPLC
基金项目:南通市科技计划项目(JC2019134)
作者单位E-mail
周谧 南通市食品药品监督检验中心 656074350@qq.com 
朱琳 南通市食品药品监督检验中心  
傅兴圣 三明市尤溪县中医医院  
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中文摘要:
      目的:测定干蟾皮饮片(生品)和制干蟾皮饮片(砂炒)中2种主要毒性成分含量,分析炮制对毒性成分的影响。方法:收集10批干蟾皮饮片,8批制干蟾皮饮片,采用HPLC-DAD法测定样品中华蟾酥毒基和脂蟾毒配基的含量。结果:在干蟾皮中华蟾酥毒基的含量均值为0.51(0.14~1.74)mg·g-1;脂蟾毒配基的含量均值为0.75(0.02~3.16)mg·g-1;在制干蟾皮中华蟾酥毒基的含量均值为0.17(0.02~0.41)mg·g-1;脂蟾毒配基的含量均值为0.22(0.004~0.87) mg·g-1。结论:炮制品中2种毒性成分的含量低于干蟾皮药材;华蟾酥毒基和脂蟾毒配基成分的含量下降是经炮制而减毒的。
英文摘要:
      Objective: The aims of present study are to determine the contents of two toxic components in B. bufo gargarizans before and after processing. Methods: Ten batches of crude samples and eight batches of processed samples were collected. An HPLC-DAD method was used to determine their contents of cinobufagin and resibufogenin. Results: The average contents of cinobufagin and resibufogenin in the crude samples were 0.51(0.14-1.74)mg·g-1 and 0.75(0.02-3.16)mg·g-1. The average contents of cinobufagin and resibufogenin in the processed samples were 0.17 (0.02-0.41)mg·g-1 and 0.22 (0.004-0.87)mg·g-1. Conclusion: The contents of cinobufagin and resibufogenin in the fried dried B. bufo gargarizans were lower than those in the raw products. The content changes of cinobufagin and resibufogenin may be one of the intrinsic mechanisms of toxicity attenuation.
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